| Class | Consequence | Cases | Controls | Odds Ratio | Case/Control P-value | De Novos | De Novo P-value |
|---|---|---|---|---|---|---|---|
| Ⅰ | PTV | 4 | 15 | 1.07 | 0.806 | — | — |
| Missense (MPC ≥ 3) | 0 | 0 | — | ||||
| Ⅱ | Missense (3 > MPC ≥ 2) | 0 | 0 | - | — | — |
Meta-analysis P-value: 0.806
Meta-analysis Q-value: 1.00
| Category | Exp. SNVs | Obs. SNVs | Constraint metrics | |
|---|---|---|---|---|
| Synonymous | 121.5 | 131 | Z = -0.68 | o/e = 1.08 |
| Missense | 309.4 | 234 | Z = 1.52 | o/e = 0.76 |
| pLoF | 28.4 | 16 | pLI = 0 | o/e = 0.56 |