| Class | Consequence | Cases | Controls | Odds Ratio | Case/Control P-value | De Novos | De Novo P-value |
|---|---|---|---|---|---|---|---|
| Ⅰ | PTV | 2 | 16 | 0.502 | 0.156 | — | — |
| Missense (MPC ≥ 3) | 0 | 0 | — | ||||
| Ⅱ | Missense (3 > MPC ≥ 2) | 0 | 0 | - | — | — |
Meta-analysis P-value: 0.156
Meta-analysis Q-value: 1.00
| Category | Exp. SNVs | Obs. SNVs | Constraint metrics | |
|---|---|---|---|---|
| Synonymous | 41.1 | 43 | Z = -0.24 | o/e = 1.05 |
| Missense | 110.6 | 102 | Z = 0.29 | o/e = 0.92 |
| pLoF | 10.6 | 10 | pLI = 0 | o/e = 0.94 |