| Class | Consequence | Cases | Controls | Odds Ratio | Case/Control P-value | De Novos | De Novo P-value |
|---|---|---|---|---|---|---|---|
| Ⅰ | PTV | 15 | 49 | 1.23 | 0.670 | — | — |
| Missense (MPC ≥ 3) | 0 | 0 | — | ||||
| Ⅱ | Missense (3 > MPC ≥ 2) | 0 | 0 | - | — | — |
Meta-analysis P-value: 0.670
Meta-analysis Q-value: 1.00
| Category | Exp. SNVs | Obs. SNVs | Constraint metrics | |
|---|---|---|---|---|
| Synonymous | 634.9 | 614 | Z = 0.65 | o/e = 0.97 |
| Missense | 1391.7 | 1244 | Z = 1.41 | o/e = 0.89 |
| pLoF | 65.9 | 21 | pLI = 0 | o/e = 0.32 |