| Class | Consequence | Cases | Controls | Odds Ratio | Case/Control P-value | De Novos | De Novo P-value |
|---|---|---|---|---|---|---|---|
| Ⅰ | PTV | 1 | 8 | 0.502 | 1.00 | — | — |
| Missense (MPC ≥ 3) | 0 | 0 | — | ||||
| Ⅱ | Missense (3 > MPC ≥ 2) | 0 | 0 | - | — | — |
Meta-analysis P-value: 1.00
Meta-analysis Q-value: 1.00
| Category | Exp. SNVs | Obs. SNVs | Constraint metrics | |
|---|---|---|---|---|
| Synonymous | 36.9 | 40 | Z = -0.4 | o/e = 1.08 |
| Missense | 105.6 | 106 | Z = -0.01 | o/e = 1 |
| pLoF | 9.4 | 6 | pLI = 0 | o/e = 0.64 |