| Class | Consequence | Cases | Controls | Odds Ratio | Case/Control P-value | De Novos | De Novo P-value |
|---|---|---|---|---|---|---|---|
| Ⅰ | PTV | 20 | 80 | 1.00 | 1.00 | — | — |
| Missense (MPC ≥ 3) | 0 | 0 | — | ||||
| Ⅱ | Missense (3 > MPC ≥ 2) | 0 | 0 | - | — | — |
Meta-analysis P-value: 1.00
Meta-analysis Q-value: 1.00
| Category | Exp. SNVs | Obs. SNVs | Constraint metrics | |
|---|---|---|---|---|
| Synonymous | 194.9 | 187 | Z = 0.44 | o/e = 0.96 |
| Missense | 514.7 | 515 | Z = 0 | o/e = 1 |
| pLoF | 46.7 | 52 | pLI = 0 | o/e = 1.11 |