Class | Consequence | Cases | Controls | Odds Ratio | Case/Control P-value | De Novos | De Novo P-value |
---|---|---|---|---|---|---|---|
Ⅰ | PTV | 2 | 10 | 0.803 | 1.00 | — | — |
Missense (MPC ≥ 3) | 0 | 0 | — | ||||
Ⅱ | Missense (3 > MPC ≥ 2) | 0 | 0 | - | — | — |
Meta-analysis P-value: 1.00
Meta-analysis Q-value: 1.00
Category | Exp. SNVs | Obs. SNVs | Constraint metrics | |
---|---|---|---|---|
Synonymous | 64 | 75 | Z = -1.08 | o/e = 1.17 |
Missense | 162.1 | 200 | Z = -1.06 | o/e = 1.23 |
pLoF | 6.1 | 3 | pLI = 0.03 | o/e = 0.49 |