| Class | Consequence | Cases | Controls | Odds Ratio | Case/Control P-value | De Novos | De Novo P-value |
|---|---|---|---|---|---|---|---|
| Ⅰ | PTV | 4 | 6 | 2.68 | 0.155 | — | — |
| Missense (MPC ≥ 3) | 0 | 0 | — | ||||
| Ⅱ | Missense (3 > MPC ≥ 2) | 0 | 0 | - | — | — |
Meta-analysis P-value: 0.155
Meta-analysis Q-value: 1.00
| Category | Exp. SNVs | Obs. SNVs | Constraint metrics | |
|---|---|---|---|---|
| Synonymous | 100.1 | 100 | Z = 0.01 | o/e = 1 |
| Missense | 237.3 | 176 | Z = 1.41 | o/e = 0.74 |
| pLoF | 14.2 | 6 | pLI = 0.01 | o/e = 0.42 |