| Class | Consequence | Cases | Controls | Odds Ratio | Case/Control P-value | De Novos | De Novo P-value |
|---|---|---|---|---|---|---|---|
| Ⅰ | PTV | 3 | 17 | 0.708 | 0.942 | — | — |
| Missense (MPC ≥ 3) | 0 | 0 | — | ||||
| Ⅱ | Missense (3 > MPC ≥ 2) | 0 | 0 | - | — | — |
Meta-analysis P-value: 0.942
Meta-analysis Q-value: 1.00
| Category | Exp. SNVs | Obs. SNVs | Constraint metrics | |
|---|---|---|---|---|
| Synonymous | 22.1 | 32 | Z = -1.65 | o/e = 1.45 |
| Missense | 60.6 | 58 | Z = 0.12 | o/e = 0.96 |
| pLoF | 8.3 | 5 | pLI = 0 | o/e = 0.61 |